Zilmax

Non-steroidal performance enhancer that increases weight gain and improves feed conversion in beef cattle. It enhances yield and carcass quality in cattle intended for meat production.

FORMULA:

Each kg contains:

Zilpaterol Hydrochloride 48 g

Vegetable of plant origin, cbp 1 kg

PHARMACEUTICAL FORM:

Granulated

PHARMACODYNAMIC PROPERTIES:

Zilpaterol HCl is a β2-adrenergic agonist. β2-adrenergic agonists act on the adipose cells of animals by increasing lipolysis (lipid lysis) and reducing lipogenesis (fat synthesis), and on muscle tissue by stimulating protein synthesis, decreasing protein lysis, and increasing the binding of insulin to muscle insulin receptors to increase glycogen lysis. The overall effect is to allocate an animal's energy toward muscle tissue deposition and reduce fat deposition.

PHARMACOKINETIC PROPERTIES:

Orally administered zilpaterol HCl is rapidly absorbed, reaching peak plasma levels (Cmax) in about 12 hours and having a disappearance half-life (t½) of approximately 12 hours. Liver tissue contains the highest levels of residues, which are primarily unchanged zilpaterol and a metabolite, deisopropyl-zilpaterol, which is approximately 20% of the residue. This metabolite has only 10% of the activity of zilpaterol. Residue levels in muscle tissue are only about 10% of those in liver tissue, and residues in adipose tissue are essentially absent.

DOSAGE AND ROUTE OF ADMINISTRATION:

Oral administration. Mix Zilmax® with the other micronutrients in the feed at a dose of 0.15 mg/kg of body weight per day (equivalent to 125 g of Zilmax®/ton of feed).